Extrapolate of the rate of deleterious mutational load in mice and other organisms has led to a rough estimate of a 1% decline in the baseline physical and mental performance attributes of populations in conditions of extreme relaxed selection pressures (both natural and sexual) per generation. This estimate may be overly conservative, however, particularly in regards to brain function.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788123/#bib64</ref> Some researchers have also argued factors that decrease deleterious mutational load in populations, such as reductions in the rate of [[inbreeding depression|inbreeding]] and pre-natal therapeutic fetus selection (the abortion of offspring with severe abnormalities revealed through pre-birth screening) may serve to counteract these effects somewhat.<ref>https://www.researchgate.net/publication/323320480_Relaxed_selection_and_mutation_accumulation_are_best_studied_empirically_Reply_to_Woodley_of_Menie_et_al</ref>
== Some incels may be mutants ==
That being said, being a mutant is not a judgement or insult. It is simply the genetic condition of having a high mutational load, much like being physically ill is not an insult.
== Some mutations are good ==