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→Mental disorders significantly reduce male fertility, substantially more than they do for women
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The researchers concluded that schizophrenia and autism were therefore under purifying selection (being "bred out", basically) in modern Western societies, with the continuing high prevalence of these conditions, possibly being maintained through new mutations (possibly due to increased paternal age). The researchers stated that it has been been supported by prior research (MacCabe et al., 2009), that the sufferers of these conditions lower fertility is likely largely due to the those that have these mental conditions being less able to find a partner to marry/have children with, and this dynamic is stronger among males who suffer from mental illness, as compared to female sufferers. | The researchers concluded that schizophrenia and autism were therefore under purifying selection (being "bred out", basically) in modern Western societies, with the continuing high prevalence of these conditions, possibly being maintained through new mutations (possibly due to increased paternal age). The researchers stated that it has been been supported by prior research (MacCabe et al., 2009), that the sufferers of these conditions lower fertility is likely largely due to the those that have these mental conditions being less able to find a partner to marry/have children with, and this dynamic is stronger among males who suffer from mental illness, as compared to female sufferers. | ||
<span style="font-size:125%">'''Figures:'''</span> | |||
[[File:Fertility_Ratios.png|500px|thumb|none|The fertility ratio is the ratio of the number of offspring each group produced compared to healthy people.]] | |||
<span style="font-size:125%">'''Quotes:'''</span> | <span style="font-size:125%">'''Quotes:'''</span> | ||
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* ''Individuals with autism showed the greatest reduction in fecundity among all examined disorders. This was not unexpected because previous investigations have shown that few individuals with autism ever married or had children [...]'' | * ''Individuals with autism showed the greatest reduction in fecundity among all examined disorders. This was not unexpected because previous investigations have shown that few individuals with autism ever married or had children [...]'' | ||
* ''Our results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism.'' | * ''Our results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism.'' | ||
* ''Depression and, to a lesser extent, substance abuse, seems to be maintained by genes that are beneficial under some circumstances (ie, in siblings) but detrimental in others (i.e, affected individuals).'' | * ''Depression and, to a lesser extent, substance abuse, seems to be maintained by genes that are beneficial under some circumstances (ie, in siblings) but detrimental in others (i.e, affected individuals).'' | ||
<span style="font-size:125%">'''References:'''</span> | <span style="font-size:125%">'''References:'''</span> | ||