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Scientific Blackpill: Difference between revisions
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→A man's muscle building capacity is primarily determined by genetics
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Carpinelli (2017), reviewed key studies regarding this topic, stating that the research provided strong evidence for individual genetic variance being the largest factor in how one responds to strength training, as compared to differences in exercise programming, etc. | Carpinelli (2017), reviewed key studies regarding this topic, stating that the research provided strong evidence for individual genetic variance being the largest factor in how one responds to strength training, as compared to differences in exercise programming, etc. | ||
He noted that Hubal et al. (2005), had earlier conducted a study on a mixed-gender cohort (n=585) who performed an | He noted that Hubal et al. (2005), had earlier conducted a study on a mixed-gender cohort (n=585) who performed an identical resistance training protocol, 3x a week for three months. It was found that the average increase in muscle growth, as measured via MRI, was 18.9%, but this varied between the subjects within a very broad range, with one individual actually losing muscle (-2%) and one gaining muscle at rate more than 3 times the average (+59%). | ||
Further on this topic, Petrella et al. (1985) recruited 66 adults and divided them into | Further on this topic, Petrella et al. (1985) recruited 66 adults and divided them into separate groups based on age, subjecting them to a program that was based on lower body exercises. They found evidence of a disparate response to resistance training among the individuals involved, congruent with the findings above, but what was also significant, was that they identified a strong relationship regarding response to resistance training and individual differences in population of satellite cells in the muscle fibre. Those found to be "extreme responsers" were also found to exhibit a much greater proliferation of the satellite cell pool, as compared to those who exhibited more modest muscle growth. | ||
One of the other factors that likely moderates individual heterogeneity in responses to resistance training is androgen receptor density. Various cell types in | One of the other factors that likely moderates individual heterogeneity in responses to resistance training is androgen receptor density. Various cell types in disparate regions of the human body contain receptors to which androgens (male sex hormones, such as testosterone) activate, and these receptors then regulate gene expression and possibly also influence muscle growth through non-genomic factors also. An individual's genetic differences in sensitivity to circulating androgens has a very large influence on pubertal development, and their overall physical phenotype. | ||
In an attempt to determine how important individual differences in androgen receptor content in the muscle was to determining response to resistance training, Morton et al. (2018) examined 49 resistance trained young men, who were assigned to either a high rep or low rep group, both groups were also administered 2 doses of 30 g of whey protein isolate per day. | In an attempt to determine how important individual differences in androgen receptor content in the muscle was to determining response to resistance training, Morton et al. (2018) examined 49 resistance trained young men, who were assigned to either a high rep or low rep group, both groups were also administered 2 doses of 30 g of whey protein isolate per day. | ||