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Testosterone: Difference between revisions
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Many studies that examine the effects of testosterone (and other hormones) on psychology are deeply flawed as they do not take these inter-hormone interactions into account, do not use particularly reliable measures of testosterone, have low sample sizes, do not take into account interindividual differences in sensitivity to androgens and do not take into account the effects prenatal and pubertal 'priming' may have on shaping the bodies response to testosterone in adulthood. Adult T-levels are also substantially related to lifestyle factors <ref>https://academic.oup.com/jcem/article/92/2/549/2566787?login=true</ref><ref>https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1019.6064&rep=rep1&type=pdf</ref> such as age, smoking, body fat percentage and general health. | Many studies that examine the effects of testosterone (and other hormones) on psychology are deeply flawed as they do not take these inter-hormone interactions into account, do not use particularly reliable measures of testosterone, have low sample sizes, do not take into account interindividual differences in sensitivity to androgens and do not take into account the effects prenatal and pubertal 'priming' may have on shaping the bodies response to testosterone in adulthood. Adult T-levels are also substantially related to lifestyle factors <ref>https://academic.oup.com/jcem/article/92/2/549/2566787?login=true</ref><ref>https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1019.6064&rep=rep1&type=pdf</ref> such as age, smoking, body fat percentage and general health. | ||
There has been a secular decline in testosterone in Western countries,<ref>https://academic.oup.com/jcem/article/92/1/196/2598434?login=true</ref> leading to sensationalist headlines regarding rampant [[soyboy|feminization]] of men being driven by this factor alone. However, other longitudinal studies have found concurrent evidence that sex-hormone-binding globulin (SHBG), a protein that binds to testosterone and makes it inert in the body, has also been decreasing on a population and cohort level.<ref>https://academic.oup.com/jcem/article/92/12/4696/2597312?login=true</ref> | There has been a secular decline in testosterone in Western countries that is independent of factors such as population aging and increased obesity,<ref>https://academic.oup.com/jcem/article/92/1/196/2598434?login=true</ref> leading to sensationalist headlines regarding rampant [[soyboy|feminization]] of men being driven by this factor alone. However, other longitudinal studies have found concurrent evidence that sex-hormone-binding globulin (SHBG), a protein that binds to testosterone and makes it inert in the body, has also been decreasing on a population and cohort level.<ref>https://academic.oup.com/jcem/article/92/12/4696/2597312?login=true</ref> | ||
If this finding proves robust, this reduction in SHBG would result in less negative feedback being exerted on men's hypothalamic-pituitary-gonadal axis (HPG axis), which would lead to the body downregulating T production as it essentially needs less to produce the desired effects. Meaning the secular decrease in T wouldn't be relevant in driving any practical differences in population level masculinization. | If this finding proves robust, this reduction in SHBG would result in less negative feedback being exerted on men's hypothalamic-pituitary-gonadal axis (HPG axis), which would lead to the body downregulating T production as it essentially needs less to produce the desired effects. Meaning the secular decrease in T wouldn't be relevant in driving any practical differences in population level masculinization. | ||