Testosterone: Difference between revisions

Testosterone (edit)

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 There has been a secular decline in testosterone in Western countries,<ref>https://academic.oup.com/jcem/article/92/1/196/2598434?login=true</ref> leading to sensationalist headlines regarding rampant [[soyboy|feminization]] of men being driven by this factor alone. However, other longitudinal studies have found concurrent evidence that sex-hormone-binding globulin (SHBG), a protein that binds to testosterone and makes it inert in the body, has also been decreasing on a population and cohort level.<ref>https://academic.oup.com/jcem/article/92/12/4696/2597312?login=true</ref>
-If this finding proves robust, this reduction in SHBG results in less negative feedback being exerted on men's hypothalamic-pituitary-gonadal axis (HPG axis), which would result in the body downregulating T production as it essentially needs less to produce the desired effects. Meaning the secular decrease in T wouldn't be relevant in driving any practical differences in population level masculinization.
+If this finding proves robust, this reduction in SHBG would result in less negative feedback being exerted on men's hypothalamic-pituitary-gonadal axis (HPG axis), which would lead to the body downregulating T production as it essentially needs less to produce the desired effects. Meaning the secular decrease in T wouldn't be relevant in driving any practical differences in population level masculinization.
 ==Dual hormone hypothesis==