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Extrapolation of the rate of deleterious mutational load in mice and other organisms has led to a rough estimate of a 1% decline in the baseline physical and mental performance attributes of populations in conditions of extreme relaxed selection pressures (both natural and sexual) per generation. This estimate may be overly conservative, however, particularly in regards to brain function. | Extrapolation of the rate of deleterious mutational load in mice and other organisms has led to a rough estimate of a 1% decline in the baseline physical and mental performance attributes of populations in conditions of extreme relaxed selection pressures (both natural and sexual) per generation. This estimate may be overly conservative, however, particularly in regards to brain function. | ||
In terms of human intelligence and mental function, it has been asserted that [[IQ|general intelligence]] has declined due to increasing mutational load in the human genome, though deleterious mutations appear to only account for up to 7% of the secular decline in general intellgence. Other factors, such as a general negative correlation between intelligence and fertility and | In terms of human intelligence and mental function, it has been asserted that [[IQ|general intelligence]] has declined due to increasing mutational load in the human genome, though deleterious mutations appear to only account for up to 7% of the secular decline in general intellgence. Other factors, such as a general negative correlation between intelligence and fertility (particularly among women) and the pollution of the environment with neurotoxins that disrupt brain function and development post-industrialization, appear to be more to blame for this apparent decline in general intelligence, a decrease that appears independent of secular increases in IQ test scores due to the [https://en.wikipedia.org/wiki/Flynn_effect Flynn Effect].<ref>https://www.sciencedirect.com/science/article/abs/pii/S0191886915301161</ref> | ||
<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788123/#bib64</ref> Some researchers have also argued factors that decrease deleterious mutational load in populations, such as reductions in the rate of [[inbreeding depression|inbreeding]] and pre-natal therapeutic fetus selection (the abortion of offspring with severe abnormalities revealed through pre-birth screening) may serve to counteract these effects somewhat.<ref>https://www.researchgate.net/publication/323320480_Relaxed_selection_and_mutation_accumulation_are_best_studied_empirically_Reply_to_Woodley_of_Menie_et_al</ref> | <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788123/#bib64</ref> Some researchers have also argued factors that decrease deleterious mutational load in populations, such as reductions in the rate of [[inbreeding depression|inbreeding]] and pre-natal therapeutic fetus selection (the abortion of offspring with severe abnormalities revealed through pre-birth screening) may serve to counteract these effects somewhat.<ref>https://www.researchgate.net/publication/323320480_Relaxed_selection_and_mutation_accumulation_are_best_studied_empirically_Reply_to_Woodley_of_Menie_et_al</ref> | ||